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nutlin-3 (c15-1879-922)

NUTLIN-3 (C005B-444076)

Catalog No.
C005B-444076
Manufacturer No.
N6287-1MG
Manufacturer Name
Sigma-Aldrich
Quantity
1
Unit of Measure
MG

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Application Nutlin-3 has been used: as a drug to stimulate p53 functions in gene transfer experiment to inject worms to verify the prevalent role of translationally controlled tumor protein (TCTP) in posterior amputated : E . :

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Application

Nutlin-3 has been used:

  • as a drug to stimulate p53 functions in gene transfer experiment
  • to inject worms to verify the prevalent role of translationally controlled tumor protein (TCTP) in posterior amputated E. eugeniae
  • as a p53 activator in cyclotherapy studies
  • as an mdm2 inhibitor to know its effect on p53 levels, cleaved caspase 3 and Poly (ADP-ribose) polymerase (PARP) cleavage

Biochem/physiol Actions

Nutlin-3, an antagonist of a human homolog of murine double minute 2 (HDM2). It has the ability to inhibit the HDM2-directed degradation of p53. Nutlin-3 can also enhance the transcriptional activities of p73.

Nutlin-3 is a Mdm2 (mouse double minute 2) antagonist, p53 pathway activator, and apoptosis inducer.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Other Notes

Relative stereochemistry; racemic mixture of (4R, 5S) and (4S, 5R) enantiomers.

Analysis Note

relative stereochemistry

Legal Information

Sold under license from Hoffman-La Roche, Inc. US patent 6,734,302.

UPC:
51142509
Condition:
New
HazmatClass:
No
MPN:
N6287-1MG
CAS:
548472-68-0
Temperature Control Device:
Yes

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