CYTOCHROME P450 2E1 ISOZYME MICROSOMES WITH B5 AND P450 REDUCTASE (C005B-104149)

Application

Cytochrome P450 is a heterogeneous family of isozymes whose primary function is to oxidize small molecules both as a function of intermediary metabolism (e.g., fatty acids) and to detoxify exogenous compounds (drugs or toxins). Alterations in the renal formation of Cytochrome P450 metabolites from arachidonic acid may participate in the formation of hypertension. Therefore, they have been identified as candidate mediators in the development of this multifactorial disease.

Biochem/physiol Actions

Cytochrome P450 is a heterogeneous family of isozymes whose primary function is to oxidize small molecules, both as a function of intermediary metabolism (e.g., fatty acids) and to detoxify exogenous compounds (drugs or toxins). Some isoforms have narrow substrate specificity, while others are promiscuous.

Analysis Note

Cytochrome c Reductase, b₅, P450 content and p-Nitrophenol Hydroxylase activity reported on a lot-specific basis.

biological source: human. Quality Level: 200. recombinant: expressed in baculovirus infected insect cells (BTI-TN-5B1-4). description: 1.0 nmole P450 2E1 per 0.5 ml vial. form: buffered aqueous solution (100 mM potassium phosphate, pH 7.4). UniProt accession no.: P05181. application(s): cell analysis. shipped in: dry ice. storage temp.: −. 70°C. Gene Information: human ... CYP2E1(1571). Storage Class Code: 10 - Combustible liquids. WGK: WGK 1. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US).