InformationBAY-885 is a highly potent and selectiveERK5inhibitor.TargetsERK5In vitroBAY-885 shows potent ERK5 kinase and transcriptional inhibition in the SN12C-MEF2 reporter cell line (IC50 = 115 nM/IC90 = 691 nM) and has no effects on a reporter control cell line with constitutive luciferase expression (SN12C-CMV-luc, IC50 > 30 μM), thereby ruling out potential effects as a general inhibitor of transcription or translation.Cell Research(from reference)Cell lines:BT-474, SK-BR-3, SNU-449, NCIH460, SN12C, MFM-223 Concentrations:0.07 nM - 20 μM Incubation Time:16 h.
Specifications and Purity: ≥99%
Molecular Formula: C25H28F3N7O2
Molecular Weight: 515.53
PubChem CID: 134128280
Isomeric SMILES: CN1CCN(CC1)C2=CC3=C(C(=NC=N3)C4CCN(CC4)C(=O)C5=C(C=C(C=C5)OC(F)(F)F)N)N=C2
- UPC:
- 42292305
- Condition:
- New
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- B414253-5mg
- CAS:
- 2307249-33-6
- Product Size:
- 5mg
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