BAY-885 (C005B-310414)

Catalog No.: C005B-310414
Manufacturer No.: SML2604-5MG
Manufacturer Name: Sigma-Aldrich
Quantity: 5
Unit of Measure: MG

Biochem/physiol Actions BAY-885 is an ATP site-targeting, potent and selective ERK5 (BMK1, MAPK7) inhibitor (IC50 = 35 nM with 250 μ:M ATP: % inhibition at 1 μ:M = 62/rat Fer, 58/human EphB3, 43/human EphA5, =20/355 kinases) with no BRD4

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Description
Specifications

Biochem/physiol Actions

BAY-885 is an ATP site-targeting, potent and selective ERK5 (BMK1, MAPK7) inhibitor (IC50 = 35 nM with 250 μM ATP; % inhibition at 1 μM = 62/rat Fer, 58/human EphB3, 43/human EphA5, =20/355 kinases) with no BRD4 affinity (20 μM), nor inhibitory potency toward hERG (10 μM) and CYP enzymes (20 μM; CYP1A2, CYP2C8, CYP2C9, CYP2D6, CYP3A4). BAY-885 potently inhibits 100 ng/mL EGF-induced, ERK5-dependent MEF2 activity (IC50 = 120 nM; SN12C-MEF2-luc reporter assay).

UPC:: 42292305
Condition:: New
HazmatClass:: No
MPN:: SML2604-5MG
CAS:: 2307249-33-6

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