InformationVUF10166 is a novel, potent and competitive antagonist for5-HT3Areceptor withKiof 0.04 nM, its affinity at 5-HT3AB receptor is significantly lower.In vitroVUF10166 shows low activity to 5-HT3AB receptor with Ki of 22 nM. VUF10166 may be used to can distinguish between 5-HT3A and 5-HT3AB receptors. VUF10166 has no activity to α7 nACh receptor. VUF10166 also acts as a partial agonist at 5-HT3A receptors with EC50 of 5.2 μM, which shows that VUF10166 is unlikely to bind in the receptor pore.In vivoCell Datacell lines:Concentrations:Incubation Time:Powder Purity:≥99%.
Specifications and Purity: 10mM in DMSO
Molecular Formula: C13H15ClN4
Molecular Weight: 262.74
- UPC:
- 41103308
- Condition:
- New
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- V407864-1ml
- CAS:
- 155584-74-0
- Product Size:
- 1ml
akash.verma@cenmed.com
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