VUF10166 is a novel, potent and competitive antagonist for 5-HT3A receptor with Ki of 0.04 nM, its affinity at 5-HT3AB receptor is significantly lower.VUF10166 shows low activity to 5-HT3AB receptor with Ki of 22 nM. VUF10166 may be used to can distinguish between 5-HT3A and 5-HT3AB receptors. VUF10166 has no activity to α7 nACh receptor. VUF10166 also acts as a partial agonist at 5-HT3A receptors with EC50 of 5.2 μM, which shows that VUF10166 is unlikely to bind in the receptor pore.
Specifications and Purity: ≥99%
Molecular Formula: C13H15ClN4
Molecular Weight: 262.74
PubChem CID: 24278976
Isomeric SMILES: CN1CCN(CC1)C2=NC3=CC=CC=C3N=C2Cl
Related Documents: https://aladdin-for-icloud-store.oss-cn-hangzhou.aliyuncs.com/aladdinsci/pdp/sds/1/V129763-SCI_dceaa55177a44fc28db19af086778669.pdf
- UPC:
- 41103308
- Condition:
- New
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- V129763-10mg
- CAS:
- 155584-74-0
- Product Size:
- 10mg
akash.verma@cenmed.com
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