TDZD-8 (C005B-286811)

Catalog No.: C005B-286811
Manufacturer No.: T8325-25MG
Manufacturer Name: Sigma-Aldrich
Quantity: 25
Unit of Measure: MG

Application TDZD-8 has been used to study the role of GSK-3 in maintaining MLL leukemia stem cell transcriptional program . TDZD-8 has also been used to analyze its effect on neural functions of the mouse olfactory bulb .

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Description
Specifications

Application

TDZD-8 has been used to study the role of GSK-3 in maintaining MLL leukemia stem cell transcriptional program. TDZD-8 has also been used to analyze its effect on neural functions of the mouse olfactory bulb.

Biochem/physiol Actions

TDZD-8 is a selective inhibitor of GSK-3, a thiadiazolidinone derivative, non-ATP competitive inhibitor of GSK-3β (IC50 = 2 μM). It does not inhibit Cdk-1/cyclin B, CK-II, PKA or PKC at >100 μM. TDZD-8 has been proposed to bind to the kinase site of GSK-3β.

Features and Benefits

This compound is featured on the GSK-3 page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

TDZD-8 is soluble in DMSO at a concentration that is greater than 10 mg/ml.

UPC:: 12141750
Condition:: New
HazmatClass:: No
MPN:: T8325-25MG
CAS:: 327036-89-5

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