TDZD-8 (C007B-298976)

Catalog No.: C007B-298976
Manufacturer No.: T409003-1ml
Manufacturer Name: Aladdin Scientific
Quantity: 1
Unit of Measure: EA

InformationTDZD-8 (NP 01139) is a non-ATP competitiveGSK-3βinhibitor withIC50of 2 μM: minimal inhibitory effect observed on CDK1, casein kinase II, PKA and PKC.In vitroTDZD-8 acts as a noncompetitive inhibitor of ATP or GS-1 binding. TDZD-8 shows no

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Description
Specifications

InformationTDZD-8 (NP 01139) is a non-ATP competitiveGSK-3βinhibitor withIC50of 2 μM; minimal inhibitory effect observed on CDK1, casein kinase II, PKA and PKC.In vitroTDZD-8 acts as a noncompetitive inhibitor of ATP or GS-1 binding. TDZD-8 shows no inhibition of PKA, PKC, Cdk-1/cyclin B or CK-II in kinase assays. TDZD-8 specifically induces cell death of primary leukemia specimens. TDZD-8 ablates leukemia progenitor and stem cells. TDZD-8 treatment induces oxidative stress. TDZD-8 induces cell death with extremely rapid cell death kinetics showing loss of membrane integrity. TDZD-8 inhibits PKC and FLT3 in primary AML specimens.In vivoCell Datacell lines：Concentrations：Incubation Time：Powder Purity:≥99%.

Specifications and Purity: 10mM in DMSO

Molecular Formula: C10H10N2O2S

Molecular Weight: 222.26

UPC:: 12141750
Condition:: New
HazmatClass:: No
WeightUOM:: LB
MPN:: T409003-1ml
CAS:: 327036-89-5
Product Size:: 1ml

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