TAK-475 (C005B-311104)

Catalog No.: C005B-311104
Manufacturer No.: SML2168-5MG
Manufacturer Name: Sigma-Aldrich
Quantity: 5
Unit of Measure: MG

Application TAK-475 has been used: as a farnesyl-diphosphate farnesyltransferase 1 (FDFT1) inhibitor to study its effects on cell signaling in pancreatic ductal adenocarcinoma cells as a squalene synthase (SQS) inhibitor to stabilize HMG-CoA

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Description
Specifications

Application

TAK-475 has been used:

as a farnesyl-diphosphate farnesyltransferase 1 (FDFT1) inhibitor to study its effects on cell signaling in pancreatic ductal adenocarcinoma cells
as a squalene synthase (SQS) inhibitor to stabilize HMG-CoA reductase (HMGCR)-dCat-ELuc proteins
as an SQS inhibitor to study its effects on the migration of prostate cancer cells

Biochem/physiol Actions

TAK-475 (Lapaquistat acetate) is a potent and selective squalene synthase inhibitor. TAK-475 effectively lowers low-density lipoprotein cholesterol in human. Clinical development of TAK-475 was discontinued due to hepatotoxicity seen in two patients receiving a high dose.

UPC:: 42202202
Condition:: New
HazmatClass:: No
MPN:: SML2168-5MG
CAS:: 189060-13-7

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