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stf-31 (c15-1724-353)

STF-31 (C005B-312530)

Catalog No.
C005B-312530
Manufacturer No.
SML1108-25MG
Manufacturer Name
Sigma-Aldrich
Quantity
25
Unit of Measure
MG

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Application STF-31 has been used in glucose transporter 1 (GLUT1) inhibition. Biochem/physiol Actions STF-31 selectively inhibits the glucose transporter GLUT1 and selectively impairs cancer cell growth of kidney and other types of cancer cells

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Application

STF-31 has been used in glucose transporter 1 (GLUT1) inhibition.

Biochem/physiol Actions

STF-31 selectively inhibits the glucose transporter GLUT1 and selectively impairs cancer cell growth of kidney and other types of cancer cells that lack the von Hippel-Lindau (VHL) tumor suppressor protein. Inactivation of VHL increases the activity of hypoxia-inducible factor transcription factor HIF, which in turn stimulates the transcription of genes involved in glucose metabolism, including the GLUT1 gene. VHL-deficient cancer cells, which include about 80% of renal cell carcinomas, are dependent on the high affinity GLUT1 transporter and aerobic glycolysis for ATP production. STF-31 binds directly to the GLUT1 transporter, blocking glucose uptake, resulting in necrosis in VHL-deficient cancer cells, but not in normal cells or cancer cells with intact VHL.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

UPC:
42201805
Condition:
New
HazmatClass:
No
MPN:
SML1108-25MG
CAS:
724741-75-7

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