STF-083010 (C005B-313417)

Catalog No.: C005B-313417
Manufacturer No.: SML0409-5MG
Manufacturer Name: Sigma-Aldrich
Quantity: 5
Unit of Measure: MG

Application STF-083010 has been used: in a study to investigate the :potential :anti-lipotoxic effect of nicotinamide and to elucidate underlying mechanism(s) as IRE1a inhibitor to study its effect on NOS 2 expression and investigate

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Description
Specifications

Application

STF-083010 has been used:

in a study to investigate the potential anti-lipotoxic effect of nicotinamide and to elucidate underlying mechanism(s)
as IRE1a inhibitor to study its effect on NOS 2 expression and investigate the underlying mechanisms in proinflammatory gene expression in astrocytes
to block endogenous XBP1 cleavage for one hour prior to palmitate exposure in order to examine whether inositol?requiring enzyme 1α (IRE1α ) activation is implicated in palmitate cytotoxicity

Biochem/physiol Actions

STF-083010 is a potent inhibitor of the ER transmembrane protein IRE1, which mediates the unfolded protein response. STF-083010 inhibits IRE1 endonuclease and mRNA splicing activity in response to endopasmic reticulum (ER) stress, but has no affect on the kinase activity of IRE1.

UPC:: 42281708
Condition:: New
HazmatClass:: No
MPN:: SML0409-5MG
CAS:: 307543-71-1

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