(S)-(+)-EPICHLOROHYDRIN 98% (97% EE/GLC) (C005B-056842)

Application

Chiral building block in the enantioselective syntheses of hydroxyisoxazolidines and (+)-cis-sylvaticin, a potential antitumor agent.

Used in the total synthesis of Macquarimicins and in the total synthesis of the macrolide RK-397.

Used to synthesize inhibitors of fatty acid oxidation as potential metabolic modulators.

Legal Information

Manufactured under license by Sterling Pharma Solutions Limited, using Jacobsen HKR technology.

Molecular Weight: 92.52. Empirical Formula: C₃H₅ClO. vapor density: 3.2 (vs air). Quality Level: 200. vapor pressure: 12.5 mmHg ( 20 °C). Assay: 98%. optical activity: [α. ]20/D +35°, c :  . 1 in methanol. optical purity: ee: 97% (GLC). autoignition temp.: 1421 . °F. expl. lim.: 21 . %. refractive index: n20/D 1.438 (lit.). bp: 92-93 . °C/360 . mmHg (lit.). density: 1.183 . g/mL . at 25 . °C (lit.). SMILES string: ClC[C@@H]1CO1. InChI: 1S/C3H5ClO/c4-1-3-2-5-3/h3H,1-2H2/t3-/m1/s1. InChI key: BRLQWZUYTZBJKN-GSVOUGTGSA-N. Pictograms: GHS02,GHS05,GHS06,GHS08. Signal Word: Danger. Hazard Statements: H226 - H301 + H311 + H331 - H314 - H317 - H350. Precautionary Statements: P202 - P210 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338. Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Carc. 1B - Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1B - Skin Sens. 1. Storage Class Code: 3 - Flammable liquids. WGK: WGK 3. Flash Point(F): 89.6 °F - closed cup. Flash Point(C): 32 °C - closed cup. Personal Protective Equipment: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter.