(R)-(-)-EPICHLOROHYDRIN 99% (98% EE/GLC) (C005B-045977)

Application

Building block for the synthesis of a key intermediate in the synthesis of stable PGI₂ analogue UT-15.

Used in the synthesis of chiral morpholines and dioxanes via a Mitsunobu diol-cyclization. Chiral building block in the enantioselective synthesis of trans-2,4-disubstituted piperidines.

Legal Information

Manufactured under license by Sterling Pharma Solutions Limited, using Jacobsen HKR technology.

Molecular Weight: 92.52. Empirical Formula: C₃H₅ClO. vapor density: 3.29 (vs air). Quality Level: 100. vapor pressure: 10 mmHg ( 16.6 °C). Assay: 99%. optical activity: [α. ]20/D −. 34°, c :  . 1 in methanol. optical purity: ee: 98% (GLC). autoignition temp.: 772 . °F. expl. lim.: 21 . %. refractive index: n20/D 1.438 (lit.). bp: 114 . °C (lit.). density: 1.180 . g/mL . at 20 . °C (lit.). SMILES string: ClC[C@H]1CO1. InChI: 1S/C3H5ClO/c4-1-3-2-5-3/h3H,1-2H2/t3-/m0/s1. InChI key: BRLQWZUYTZBJKN-VKHMYHEASA-N. Pictograms: GHS02,GHS05,GHS06,GHS08. Signal Word: Danger. Hazard Statements: H226 - H301 + H311 + H331 - H314 - H317 - H350. Precautionary Statements: P202 - P210 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338. Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Carc. 1B - Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1B - Skin Sens. 1. Storage Class Code: 3 - Flammable liquids. WGK: WGK 3. Flash Point(F): 89.6 °F - closed cup. Flash Point(C): 32 °C - closed cup. Personal Protective Equipment: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter.