RUPHOS PD G3 95% (C005B-018218)

General description

RuPhos Pd G3 is a third generation (G3) Buchwald precatalyst that can be used in cross-coupling reactions for the formation of C-C, C–N, C–O, C–F, C–CF3, and C–S bonds. It is air-, moisture-, and thermally-stable and is highly soluble in a wide range of common organic solvents. Some of its unique features include lower catalyst loadings, shorter reaction time, efficient formation of the active catalytic species and accurate control of ligand: palladium ratio.

Application

RuPhos Pd G3 can be used as a pre-catalyst in the following protocols:

• Palladium-catalyzed Suzuki coupling of 5-p-toluenesulfonyltetrazoles with arylboronic acids to synthesize 1,5-disubstituted tetrazoles.
• Suzuki-Miyaura catalyst-transfer polycondensation (SCTP) of 3-alkylthiophenes in the presence of N-methylimidodiacetic (MIDA)-boronate monomers.
• Suzuki-Miyaura-cross-coupling of aminothiophenes.

For small scale and high throughput uses, product is also available as ChemBeads (928283)

Molecular Weight: 836.37. Empirical Formula: C₄₃H₅₆NO₅PPdS. Quality Level: 100. Assay: 98%. form: solid. feature: generation 3. reaction suitability: core: palladium, reaction type: Buchwald-Hartwig Cross Coupling Reaction, reaction type: Heck Reaction, reaction type: Hiyama Coupling, reaction type: Negishi Coupling, reaction type: Sonogashira Coupling, reaction type: Stille Coupling, reaction type: Suzuki-Miyaura Coupling, reagent type: catalyst
reaction type: Cross Couplings. mp: 188-196 . °C (decomposition). functional group: phosphine. SMILES string: CS(: O)(: O)O[Pd]c1ccccc1-c2ccccc2N.CC(C)Oc3cccc(OC(C)C)c3-c4ccccc4P(C5CCCCC5)C6CCCCC6. InChI: 1S/C30H43O2P.C12H10N.CH4O3S.Pd/c1-22(2)31-27-19-13-20-28(32-23(3)4)30(27)26-18-11-12-21-29(26)33(24-14-7-5-8-15-24)25-16-9-6-10-17-25. 13-12-9-5-4-8-11(12)10-6-2-1-3-7-10. 1-5(2,3)4. /h11-13,18-25H,5-10,14-17H2,1-4H3. 1-6,8-9H,13H2. 1H3,(H,2,3,4). /q. . . +1/p-1. InChI key: AXZLIMCJMPNFFU-UHFFFAOYSA-M. Pictograms: GHS07. Signal Word: Warning. Hazard Statements: H315 - H319 - H335 - H412. Precautionary Statements: P273 - P302 + P352 - P305 + P351 + P338. Hazard Classifications: Aquatic Chronic 3 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3. Target Organs: Respiratory system. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable.