RUPHOS PD G3 CHEMBEADS

General description

RuPhos Pd G3 is a third generation (G3) Buchwald precatalyst that can be used in cross-coupling reactions for the formation of C-C, C–N, C–O, C–F, C–CF₃, and C–S bonds. It is air-, moisture-, and thermally-stable and is highly soluble in a wide range of common organic solvents. Some of its unique features include lower catalyst loadings, shorter reaction time, efficient formation of the active catalytic species and accurate control of ligand: palladium ratio.

For larger scale uses, product also available in powdered form (763403)

Application

RuPhos Pd G3 can be used as a pre-catalyst in the following protocols:

Palladium-catalyzed Suzuki coupling of 5-p-toluenesulfonyltetrazoles with arylboronic acids to synthesize 1,5-disubstituted tetrazoles.Suzuki-Miyaura catalyst-transfer polycondensation (SCTP) of 3-alkylthiophenes in the presence of N-methylimidodiacetic (MIDA)-boronate monomers. Suzuki-Miyaura-cross-coupling of aminothiophenes.

ChemBeads are chemical coated glass beads. ChemBeads offer improved flowability and chemical uniformity perfect for automated solid dispensing and high-throughput experimentation. The method of creating ChemBeads uses no other chemicals or surfactants allowing the user to accurately dispense sub-milligram amounts of chemical.

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Other Notes

High-Throughput Reaction Screening with Nanomoles of Solid Reagents Coated on Glass Beads

Versatile Methods to Dispense Sub-Milligram Quantities of Solids using Chemical Coated Beads for High-Throughput Experimentation

ChemBead Enabled High-Throughput Cross-Electrophile Coupling Reveals a New Complementary Ligand

Molecular Weight: 836.37. Empirical Formula: C₄₃H₅₆NO₅PPdS. form: solid. Quality Level: 100. reaction suitability: reagent type: catalyst
reaction type: Cross Couplings. extent of labeling: ~5 . wt. % loading of catalyst. SMILES string: NC1: C(C2: C([Pd](OS(: O)(C): O)P(C3CCCCC3)(C4CCCCC4)C5: CC: CC: C5C6: C(C: CC: C6OC(C)C)OC(C)C)C: CC: C2)C: CC: C1. Pictograms: GHS08. Signal Word: Danger. Hazard Statements: H350i. Precautionary Statements: P201 - P202 - P280 - P308 + P313 - P405 - P501. Hazard Classifications: Carc. 1B Inhalation. Storage Class Code: 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable.