RO-3306 (C005B-313215)

Catalog No.: C005B-313215
Manufacturer No.: SML0569-25MG
Manufacturer Name: Sigma-Aldrich
Quantity: 25
Unit of Measure: MG

Application RO-3306 has been used: To study the significance of CA4-mediated cytotoxicity in mitotic arrest In cell cycle synchronization to conduct a study on proteomics As a CDK1 inhibitor, to prevent early mitotic entry

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Description
Specifications

Application

RO-3306 has been used:

To study the significance of CA4-mediated cytotoxicity in mitotic arrest
In cell cycle synchronization to conduct a study on proteomics
As a CDK1 inhibitor, to prevent early mitotic entry

Biochem/physiol Actions

CDK1 (cyclin dependent kinase 1) is considered to be the â€œmaster switchâ€ in cell division, which maintains the mitotic state of cells.

RO-3306 is a selective ATP-competitive inhibitor of CDK1. It inhibites CDK1 cyclin B1 activity with Ki of 35 nM, nearly 10-fold selectivity relative to CDK2/cyclin E and over 50-fold relative to CDK4/cyclin D. RO-3306 has been used to cause cell cycle arrest at the G2/M boundary.

Features and Benefits

This compound is featured on the CDKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

UPC:: 85121706
Condition:: New
HazmatClass:: No
MPN:: SML0569-25MG
CAS:: 872573-93-8

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