Ro-3306

InformationRo-3306 RO-3306 is an ATP-competitive, and selective CDK1 inhibitor with K i of 20 nM, >15-fold selectivity against a diverse panel of human kinases. RO-3306 enhances p53-mediated Bax activation and mitochondrial apoptosis .In vitroRO-3306 inhibits CDK1/cyclin B1, CDK1/cyclin A, CDK2/cyclin E, and CDK4/cyclin D activity with Ki of 35 nM, 110 nM, 340 nM, and over 2000 nM, respectively. Treatment of HCT116, SW480, and HeLa cells with RO-3306 for 20 h leads to a complete block of the cell cycle in the G2/M phase. The proliferation of both HCT116 and SW480 is effectively blocked by RO-3306. RO-3306 appears to be more proapoptotic in cancer cells (HCT116 and SW480) than nontumorigenic cells (MCF 10A and MCF 12A). RO-3306 effectively arrests oocyte maturation at a concentration of 10 μM.In vivoCell Datacell lines：MM cell lines, patient MM cells, and PBMCsConcentrations：20 μMIncubation Time：72 hPowder Purity:≥98%.

Specifications and Purity: 10mM in DMSO

Molecular Formula: C18H13N3OS2

Molecular Weight: 351.45