PD-L1-IN-1 is a potent PD-L1 inhibitor with an IC50 of 115 nM. PD-L1-IN-1 strongly binds with the PD-L1 protein and challenged it in a co-culture of PD-L1 expressing cancer cells (PC9 and HCC827 cells) and peripheral blood mononuclear cells enhanced antitumor immune activity of the latter. PD-L1-IN-1 significantly increased interferon γ release and apoptotic induction of cancer cells, with low cytotoxicity in healthy cells.
Specifications and Purity: ≥99%
Molecular Formula: C21H23N5O2
Molecular Weight: 377.44
- UPC:
- 51201805
- Condition:
- New
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- P659082-1mg
- Product Size:
- 1mg
akash.verma@cenmed.com
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