Name: N-ACETYL-ASP-GLU-VAL-ASP-AL (C005B-021591)
SKU: C005B-021591
Availability: OutOfStock

N-ACETYL-ASP-GLU-VAL-ASP-AL (C005B-021591)

Catalog No.

C005B-021591

Manufacturer No.

A0835-1MG

Manufacturer Name

Sigma-Aldrich

Quantity

Unit of Measure

Amino Acid Sequence NAc-Asp-Glu-Val-Asp-al General description N -Acetyl-Asp-Glu-Val-Asp-al (Ac-DEVD-CHO) is a tetrapeptide with N-terminal acetylation and C-terminal aldehyde conjugation. Application N -Acetyl-Asp-Glu-Val-Asp-al has been used as a

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Description
Specifications

Amino Acid Sequence

NAc-Asp-Glu-Val-Asp-al

General description

N-Acetyl-Asp-Glu-Val-Asp-al (Ac-DEVD-CHO) is a tetrapeptide with N-terminal acetylation and C-terminal aldehyde conjugation.

Application

N-Acetyl-Asp-Glu-Val-Asp-al has been used as a caspase inhibitor in muscle samples, smooth muscle cells and Jurkat T-cells.

Biochem/physiol Actions

N-Acetyl-Asp-Glu-Val-Asp-al (Ac-DEVD-CHO) aids in the recovery of stunned myocardium by its caspase inhibition functionality.

Reversible inhibitor of IL-1β converting enzyme (ICE); inhibits poly(ADP-ribose) polymerase cleavage by apopain (caspase 3).

Molecular Weight: 502.47. Empirical Formula: C₂₀H₃₀N₄O₁₁. biological source: synthetic. Quality Level: 100. Assay: ≥. 95%. form: powder. color: white. solubility: H₂O: 1 . mg/mL. storage temp.: −. 20Â°C. SMILES string: [H]C(: O)C(CC(O): O)NC(: O)C(NC(: O)C(CCC(O): O)NC(: O)C(CC(O): O)NC(C): O)C(C)C. InChI: 1S/C20H30N4O11/c1-9(2)17(20(35)22-11(8-25)6-15(29)30)24-18(33)12(4-5-14(27)28)23-19(34)13(7-16(31)32)21-10(3)26/h8-9,11-13,17H,4-7H2,1-3H3,(H,21,26)(H,22,35)(H,23,34)(H,24,33)(H,27,28)(H,29,30)(H,31,32). InChI key: UMBVAPCONCILTL-UHFFFAOYSA-N. Gene Information: human ... CASP1(834), CASP3(836), CASP7(840), CASP8(841). Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: Eyeshields, Gloves, type N95 (US).