Biochem/physiol Actions
MR6-31-2, a CNS penetrant ebselen analog, is a potent inhibitor of SARS-CoV-2 Mpro that bind at the Mpro catalytic site. MR6-31-2 donates a selenium atom, forming a covalent bond and blocking the histidine-Cys catalytic dyad. It exhibits good neuroprotective effects and low cytotoxicity in cell-based and mouse models of motor neuron disease. MR6-31-2 covalently binds to A4V superoxide dismutase-1 (SOD1) and promotes its thermal stability.
- UPC:
- 41113402
- Condition:
- New
- HazmatClass:
- No
- MPN:
- SML3242-25MG
akash.verma@cenmed.com
(732) 447-1115





