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ml390

ML390 (C007B-231044)

Catalog No.
C007B-231044
Manufacturer No.
M413994-25mg
Manufacturer Name
Aladdin Scientific
Quantity
1
Unit of Measure
EA

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InformationML390 ML390 is a human DHODH inhibitor with an IC50 of 0.56 μM and induces differentiation in acute myeloid leukemia.TargetsDHODH (Cell-free assay) 0.56 μMIn vitroML390 was active with an ED50 (effective concentration triggering 50% of

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InformationML390 ML390 is a human DHODH inhibitor with an IC50 of 0.56 μM and induces differentiation in acute myeloid leukemia.TargetsDHODH (Cell-free assay) 0.56 μMIn vitroML390 was active with an ED50 (effective concentration triggering 50% of its maximal differentiation activity) of 2 μM in murine and human AML cell lines, offering insight into the mechanism of overcoming differentiation arrest. DHODH inhibitors demonstrated effective at prolonging survival in animal models of leukemia.Cell Research(from reference)Cell lines：Lys-GFP-ER-HoxA9 cells Concentrations：10 μM Incubation Time：48 h.

Specifications and Purity: ≥99%

Molecular Formula: C21H21F3N2O3

Molecular Weight: 406.4

PubChem CID: 71768304

Isomeric SMILES: C1C[C@H](C2=CC=CC=C2C1)NC(=O)CCNC(=O)C3=CC=C(C=C3)OC(F)(F)F

Related Documents: https://aladdin-for-icloud-store.oss-cn-hangzhou.aliyuncs.com/aladdinsci/pdp/sds/1/M413994-SCI_be43720423c7374d6ecf7c9a6eaed732.pdf

UPC:
41104301
Condition:
New
HazmatClass:
No
WeightUOM:
LB
MPN:
M413994-25mg
CAS:
2029049-79-2
Product Size:
25mg
Hazard Statement Codes:
H335:H319:H315:H302
Precautionary Statement Codes:
P305+P351+P338:P261

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