Lotilaner is a parasiticide , acts as a potent non-competitive antagonist of insects GABACl receptors , with an IC 50 of 23.84 nM for Drosophila melanogaster GABA receptor . No effect on a dog GABAA receptorIn VitroLotilaner shows IC 50 s of 38.25 ± 3.75, 52.40 ± 4.54, 36.79 ± 4.39 nM for Drosophila melanogaster dieldrin/fipronil-resistant forms (DmR2), Lepeophtheirus salmonis (Ls) and Rhipicephalus microplus (Rm) GABACl receptors, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:IC50: 23.84 nM (DmS-GABA), 38.25 nM (DmR2-GABA), 52.40 nM (Ls-GABA1), 36.79 nM (Rm-GABA).
Specifications and Purity: ≥99%
Molecular Formula: C20H14Cl3F6N3O3S
Molecular Weight: 596.76
PubChem CID: 76959255
Isomeric SMILES: CC1=C(SC(=C1)C2=NO[C@@](C2)(C3=CC(=C(C(=C3)Cl)Cl)Cl)C(F)(F)F)C(=O)NCC(=O)NCC(F)(F)F
- UPC:
- 41103813
- Condition:
- New
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- L651016-25mg
- CAS:
- 1369852-71-0
- Product Size:
- 25mg
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