Lck inhibitor 2 is a bis-anilinopyrimidine inhibitor of tyrosine kinases including LCK, BTK , LYN, SYK , and TXK. The IC50 values are 13nM, 9nM, 3nM, 26nM and 2nM for Lck, Btk , Lyn, Btk and Txk respectivelyIC50 Value: 13 nM(Lck) Target: Src family kinaseLck inhibitor 2(Compound 9) inhibited 48 kinases with %control < 1 (33 of them tyrosine kinases, almost half of the 71 tyrosine kinases in the panel). A further 27 kinases were bound with %control < 10. Kd values for 16 kinases were determined and found to be below 100 nM. These included TXK (10 nM).Form:Solid.
Specifications and Purity: ≥99%
Molecular Formula: C18H17N5O2
Molecular Weight: 335.36
PubChem CID: 25138012
Isomeric SMILES: CC1=C(C=C(C=C1)O)NC2=NC(=NC=C2)NC3=CC=CC(=C3)C(=O)N
- UPC:
- 51111602
- Condition:
- New
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- L648683-100mg
- CAS:
- 944795-06-6
- Product Size:
- 100mg
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