KR-32568 (C005B-082665)

Biochem/physiol Actions

Sodium/hydrogen exchanger-1 (NHE-1) inhibitor; IC₅₀ = 0.23 μM; inhibited NHE-1-mediated rabbit platelet swelling; in anesthetized rats, reduced infarct size from 67% (control) to 43% (at 0.1 mg/kg) and 24% (at 1.0 mg/kg); reduced number of ventricular premature beats from 530 to 266 (at 0.1 mg/kg) and 115 (at 1.0 mg/kg); reduced ventricular fibrillation incidence from 17 to 8 (0.1 mg/kg) and 0 (1.0 mg/kg); implications for research and treatment of myocardial ischemic diseases.

Molecular Weight: 261.25. Empirical Formula: C₁₃H₁₂FN₃O₂. Quality Level: 100. Assay: ≥. 98% (HPLC). form: solid. color: white. solubility: DMSO: ~10 . mg/mL. storage temp.: 2-8°C. SMILES string: Cc1ccc(F)cc1-c2ccc(o2)C(: O)NC(N): N. InChI: 1S/C13H12FN3O2/c1-7-2-3-8(14)6-9(7)10-4-5-11(19-10)12(18)17-13(15)16/h2-6H,1H3,(H4,15,16,17,18). InChI key: DTLDHYBZLVASJQ-UHFFFAOYSA-N. Gene Information: human ... SLC9A1(6548). Pictograms: GHS07. Signal Word: Warning. Hazard Statements: H302 - H315 - H319 - H335. Precautionary Statements: P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338. Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3. Target Organs: Respiratory system. Storage Class Code: 10 - Combustible liquids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter.