INTERLEUKIN-13 HUMAN RECOMBINANT

Biochem/physiol Actions

IL-13 is known to be overexpressed in glioblastoma tumors and cell lines. Elevated IL-13 expression is also observed in parasitic infections. It stimulates fibrosis in many infectious diseases, and acts as a profibrogenic factor.

Interleukin-13 is a pleiotropic cytokine produced by activated Th2 cells in the mouse and human. IL-13 is secreted mainly as an unglycosylated protein of 132 amino acids with a molecular weight of 10,000 daltons. A 4.3kb DNA fragment of the mouse IL-13 gene was sequenced and occurs as a single copy mapping a chromosome 11. In the human, a 4.6 kb DNA segment of the IL-13 gene occurs as a single copy and maps to chromosome 5. IL-13 induces B cell proliferation and also induces IgE switching. The proliferative activity of human and mouse IL-13 products are tested in culture using the human erythroleukemic cell line TF-1.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 250 μg BSA.

biological source: human. Quality Level: 200. recombinant: expressed in E. coli. Assay: ≥. 97% (SDS-PAGE). form: lyophilized powder. potency: <. 10.000 . ng/mL ED₅₀. mol wt: 12 . kDa. packaging: pkg of 10 . μ. g. technique(s): cell culture | mammalian: suitable. impurities: endotoxin, tested. color: white. UniProt accession no.: P35225. storage temp.: −. 20°C. Gene Information: human ... IL13(3596). Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: Eyeshields, Gloves, type N95 (US).