akash.verma@cenmed.com
(732) 447-1115
Biochem/physiol Actions
Interleukin-12 (IL-12) was identified as a factor secreted by human Epstein-Barr (EBV)-transformed B cell lines. IL-12, or Natural Killer Cell Stimulatory Factor (NKSF), is a 75 kDa disulfide-linked heterodimer of a 35 kDa subunit and 40 kDa subunit. IL-12 is produced predominantly by monocytes and NK cells and induces T cells and NK cells to produce IFN-γ. Human IL-12 is not active on mouse cells, but murine IL-12 is active on both murine and human lymphocytes. The biological activity of recombinant human IL-12 was measured by its ability to stimulate the proliferation of PHA-activated human T lymphoblasts. IL-12 has anti-angiogenic properties.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 0.25 mg bovine serum albumin.
biological source: human. Quality Level: 200. recombinant: expressed in baculovirus infected Sf21 cells. Assay: ≥. 97% (SDS-PAGE and N-terminal analysis). form: lyophilized powder. potency: 0.01-0.05 . ng/mL ED50. mol wt: glycoprotein 75 . kDa. packaging: pkg of 5 . μ. g. technique(s): cell culture | mammalian: suitable. impurities: endotoxin, tested. UniProt accession no.: P29460>P29459,P29460. storage temp.: −. 20°C. Gene Information: human ... IL12A(3592), IL12B(3593). Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: Eyeshields, Gloves, type N95 (US).
- UPC:
- 51201600
- Condition:
- New
- HazmatClass:
- No
- MPN:
- I2276-5UG
