INTERLEUKIN-5 HUMAN RECOMBINANT EXPRESSED IN SF 21 CELLS

Biochem/physiol Actions

IL-5 (interleukin-5) is a maturation and differentiation factor for eosinophils. Thus, it is associated with allergy and related disorders. IL-5 association with its receptor causes activation of MEK/ERK (mitogen activated protein kinase kinase/extracellular-regulated kinase), p38 MAPK (mitogen activated protein kinase) and JAK/STAT (Janus kinase/signal transducer and activator of transcription) pathways.

Interleukin-5 is a product of activated T lymphocytes and exhibits activity on eosinophils, B cells and thymocytes. Synonyms or biological activities attributed to IL-5 include: EDF (eosinophil differentiating factor), BCGF-II (B cell growth factor-II), TRF (T cell replacing factor), IgA-EF (IgA enhancing factor) and EO-CSF (eosinophil colony stimulating factor). Natural IL-5 is a 45-50 kDa dimeric glycoprotein, although glycosylation is not required for activity. Human and mouse IL-5 exhibit homology at the nucleotide and amino acid levels and show species cross-reactivity.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 0.1 mg bovine serum albumin.

biological source: human. Quality Level: 200. recombinant: expressed in baculovirus infected Sf21 cells. Assay: ≥. 97% (SDS-PAGE). form: lyophilized powder. potency: 0.1-0.5 . ng/mL EC₅₀. mol wt: 32-34 . kDa. packaging: pkg of 5 . μ. g. concentration: 0.5-10 . ng/mL. technique(s): cell culture | mammalian: suitable. impurities: endotoxin, tested. UniProt accession no.: P05113. storage temp.: −. 20°C. Gene Information: human ... IL5(3567). Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: Eyeshields, Gloves, type N95 (US).