INTERLEUKIN-3 MOUSE

General description

IL-3 is a hematopoietic growth factor that promotes the survival, differentiation and proliferation of committed progenitor cells of the megakaryocyte, granulocyte-macrophage, erythroid, eosinophil, basophil and mast cell lineages. Produced by T cells, mast cells and eosinophils, IL-3 enhances thrombopoieses, phagocytosis, and antibody-mediated cellular cytotoxicity. Its ability to activate monocytes suggests that IL-3 may have additional immunoregulatory roles. Many of the IL-3 activities depend upon co-stimulation with other cytokines. IL-3 is species-specific, variably glycosylated cytokine. Recombinant murine IL-3 is a 15.1 kDa globular protein containing 135 amino acid residues.

Biochem/physiol Actions

IL-3 is a hematopoietic growth factor that promotes the survival, differentiation and proliferation of committed progenitor cells of the megakaryocyte, granulocyte-macrophage, erythroid, eosinophil, basophil and mast cell lineages. Recombinant murine IL-3 is a 15.1 kDa globular protein containing 135 amino acid residues.

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a stabilizer (example 5% Trehalose) and store in working aliquots at -20°C to -80°C.

biological source: mouse. Quality Level: 200. recombinant: expressed in E. coli. Assay: ≥. 98% (SDS-PAGE). form: lyophilized. mol wt: 15.1 . kDa. packaging: pkg of 10 . μ. g. technique(s): cell culture | mammalian: suitable. impurities: <. 0.1 . EU/μ. g endotoxin, tested. color: white. UniProt accession no.: , P01586. shipped in: dry ice. storage temp.: −. 20°C. Gene Information: mouse ... IL3(16187). Storage Class Code: 11 - Combustible Solids. WGK: WGK 2. Flash Point(F): Not applicable. Flash Point(C): Not applicable.