GLY-PRO-ARG-PRO AMIDE ACETATE (C005B-013045)

Amino Acid Sequence

Gly-Pro-Arg-Pro-NH2

General description

Gly-Pro-Arg-Pro is a peptide that mimics the N-terminal Gly-Pro-Arg region in the a chain of fibrin protein.

Application

Gly-Pro-Arg-Pro amide has been used-

• as a constituent of buffer during fluid-phase and bound thrombin inhibition assays, to determine the activity of thrombin
• for blocking fibrin polymerization and preventing fibrin clot formation in presence of α-thrombin, in blood obtained from mice
• during preparation of human soluble fibrin, to block the polymerization of soluble fibrin

Biochem/physiol Actions

Gly-Pro-Arg-Pro peptide suppresses the early steps of fibrin polymerization. The amide derivative of this peptide prevents the degradation of fibrinogen and fragment D by plasmin, even in the presence of EGTA (ethylene glycol-bis(β-aminoethyl ether)-N,N,N′,N′-tetraacetic acid).

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Molecular Weight: 424.50. Empirical Formula: C₁₈H₃₂N₈O₄. Quality Level: 200. Assay: ≥. 97% (HPLC). UniProt accession no.: P02751, P04937, P11276. storage temp.: −. 20°C. SMILES string: NCC(: O)N1CCC[C@H]1C(: O)N[C@@H](CCCNC(N): N)C(: O)N2CCC[C@H]2C(N): O. InChI: 1S/C18H32N8O4/c19-10-14(27)25-8-3-6-13(25)16(29)24-11(4-1-7-23-18(21)22)17(30)26-9-2-5-12(26)15(20)28/h11-13H,1-10,19H2,(H2,20,28)(H,24,29)(H4,21,22,23)/t11-,12-,13-/m0/s1. InChI key: SCCTZYGEMPQRCV-AVGNSLFASA-N. Gene Information: human ... FN1(2335)
mouse ... FN1(14268)
rat ... FN1(25661). Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: Eyeshields, Gloves, type N95 (US).