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geldanamycin ready made solution (c15-1724-134)

GELDANAMYCIN READY MADE SOLUTION (C005B-475088)

Catalog No.
C005B-475088
Manufacturer No.
SML1278-1ML
Manufacturer Name
Sigma-Aldrich
Quantity
1
Unit of Measure
ML

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General description Chemical structure: benzenoid Application Geldanamycin Ready-Made Solution has been used as a heat shock protein 90 (Hsp90) inhibitor to pre-treat proteosome holo-enzyme during proteasome assay to study the role of proteasome

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General description

Chemical structure: benzenoid

Application

Geldanamycin Ready-Made Solution has been used as a heat shock protein 90 (Hsp90) inhibitor to pre-treat proteosome holo-enzyme during proteasome assay to study the role of proteasome on fibril fragmentation.

Biochem/physiol Actions

Geldanamycin is a benzoquinone ansamycin and is a well known tyrosine kinase inhibitor. It possesses anticancer effects and shows therapeutic effects against osteosarcoma.

Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines. Geldanamycin binds specifically to the heat shock protein Hsp90 and to its endoplasmic reticulum homologue GP96, and thus interferes with conformational maturation of proteins and the cellular stress response. In addition, Geldanamycin is a potent inhibitor of the nuclear hormone receptor family.

UPC:
51111704
Condition:
New
HazmatClass:
Yes
MPN:
SML1278-1ML
CAS:
30562-34-6
Temperature Control Device:
Yes

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