CLARITHROMYCIN READY MADE SOLUTION (C005B-475260)

General description

Clarithromycin is a macrolide antibiotic, which has both antibacterial and anti-inflammatory actions. It is a semi-synthetic 14-membered derivative of erythromycin A, which is resistant to degradation under acidic conditions.

Application

Clarithromycin may be used for-

• the study of the effects of clarithromycin on rate-dependent changes in QT, T_p-e and proarrhythmic events performed on arterially perfused rabbit left ventricular wedge preparations
• the culture of parasites expressing GFP (green fluorescence protein) targeted to the apicoplast, to be further used for microscopy-based assays
• the study of the synergism of NAB741 with clarithromycin in microtiter plates.

Biochem/physiol Actions

Macrolides, such as clarithromycin, prevent protein synthesis in bacteria, by binding to 50S ribosomal subunit. It also binds to other ribosomal proteins, and prevents the translocation of pepti-dyl-tRNA. In patients with refractory asthma, it is capable of regulating the levels of interleukin-8 (IL-8), and neutrophil accumulation and activation in lungs. Thus, it might be used as an additional therapy in asthma to reduce noneosinophilic airway inflammation.

Packaging

2ML

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Combustible liquids