Ezatiostat (C007B-155059)

InformationEzatiostat Ezatiostat (TER199, TLK199, Telintra), a tripeptide analog of glutathione, is a peptidomimetic inhibitor of Glutathione S-transferase P1-1 (GSTP1-1) . Ezatiostat activates c-Jun NH2 terminal kinase (JNK1) and ERK1/ERK2 and induces apoptosis .TargetsGSTP1-1 ; JNK1 ; ERK1/ERK2In vitroSelection of a resistant clone of an HL60 tumor cell line through chronic exposure to Ezatiostat (TLK199) results in cells with elevated activities of c-Jun NH2 terminal kinase (JNK1) and ERK1/ERK2, and allows the cells to proliferate under stress conditions that induced high levels of apoptosis in the wild type cells.In vivoEzatiostat (TLK199) stimulates both lymphocyte production and bone marrow progenitor (colony-forming unitgranulocyte macrophage) proliferation, but only in GSTπ+/+ and not in GSTπ-/- animals.Cell Research(from reference)Cell lines：Human myeloid leukemic cells (HL60) Concentrations：2.5 μM - 50 μM Incubation Time：8 h, 24 h.

Specifications and Purity: 10mM in DMSO

Molecular Formula: C27H35N3O6S

Molecular Weight: 529.65

PubChem CID: 5310939

Isomeric SMILES: CCOC(=O)[C@H](CCC(=O)N[C@@H](CSCC1=CC=CC=C1)C(=O)N[C@H](C2=CC=CC=C2)C(=O)OCC)N