Evodiamine is a quinozole alkaloid isolated from Evodia rutaecarpa, described as an agonist of the VR1 (vanilloid receptor subtype 1, TRPV1) with affinity (Ki = 5.95 microM) comparable to that of the prototypical VR1 chemical activator Capsaicin .Evodiamine induction of 45Ca2+ uptake was competitively antagonized by the Capsaicin antagonist Capsazepine .Evodiamine is described to inhibit prostaglandin E2 synthesis, cyclooxygenase-2 induction and NF-κB activation, producing antiinflammatory effects.
Specifications and Purity: 10mM in DMSO
Molecular Formula: C19H17N3O
Molecular Weight: 303.36
PubChem CID: 442088
Isomeric SMILES: CN1[C@@H]2C3=C(CCN2C(=O)C4=CC=CC=C41)C5=CC=CC=C5N3
- UPC:
- 51131508
- Condition:
- New
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- E424446-1ml
- CAS:
- 518-17-2
- Product Size:
- 1ml
akash.verma@cenmed.com
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