ESTRONE (C005B-046922)

General description

Estrone is a weak form of estrogen and exists as estrone sulphate. Estrone is a luteolytic estrogen produced by the corpus luteum. In the follicle, estrone is synthesized from androstenedione by the action of cytochrome P450 aromatase.

Application

Estrone has been used:

• as medium supplement for hormone based degranulation studies of natural killer cells
• as an endocrine disrupting compound for screening bacterial biosensor in toxic water.
• as medium component for monitoring fatty acid synthase (FASN) activity in breast adenocarcinoma cell lines

Biochem/physiol Actions

Estrone is an agonist for the estrogen receptor. The estradiol to estrone interconversion is favourable in menopause. Oral hormone replacement therapy (HRT) of estradiol-17β increases circulating levels of estrone.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Molecular Weight: 270.37. Empirical Formula: C₁₈H₂₂O₂. biological source: synthetic (organic). Quality Level: 200. sterility: non-sterile. Assay: ≥. 99%. form: powder. mp: 258-260 . °C (lit.). solubility: dioxane: 50 . mg/mL, clear, colorless to very faintly yellow. shipped in: ambient. storage temp.: room temp. SMILES string: C[C@]12CC[C@H]3[C@@H](CCc4cc(O)ccc34)[C@@H]1CCC2: O. InChI: 1S/C18H22O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-16,19H,2,4,6-9H2,1H3/t14-,15-,16+,18+/m1/s1. InChI key: DNXHEGUUPJUMQT-CBZIJGRNSA-N. Gene Information: human ... ESR1(2099), ESR2(2100), ESRRA(2101), ESRRB(2103), HSD17B1(3292), SERPINA6(866)
mouse ... Esr1(13982)
rat ... Esr1(24890). Pictograms: GHS08. Signal Word: Danger. Hazard Statements: H351 - H360FD - H362. Precautionary Statements: P202 - P260 - P263 - P264 - P270 - P308 + P313. Hazard Classifications: Carc. 2 - Lact. - Repr. 1A. Storage Class Code: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges.