ESTRADIOL MEETS USP TESTING SPECIFICATIONS (C005B-044978)

Biochem/physiol Actions

The major estrogen secreted by the premenopausal ovary. Estrogens direct the development of the female phenotype in embryogenesis and during puberty by regulating gene transcription and, thus, protein synthesis. It also induces the production of gonadotropins which, in turn, induce ovulation. Exposure to estradiol increases breast cancer incidence and proliferation.

Molecular Weight: 272.38. Empirical Formula: C₁₈H₂₄O₂. Agency: USP/NF, meets USP testing specifications. Quality Level: 200. form: powder. mp: 176-180 . °C (lit.). application(s): pharmaceutical (small molecule). SMILES string: O[C@H]1CC[C@@]2([H])[C@]3([H])CCC4: CC(O): CC: C4[C@@]3([H])CC[C@@]21C. InChI: 1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1. InChI key: VOXZDWNPVJITMN-ZBRFXRBCSA-N. Gene Information: human ... ESR1(2099), ESR2(2100), ESRRB(2103), GPER(2852), SERPINA6(866)
mouse ... Esr1(13982), Esr2(13983), Esrra(26379)
rat ... Afp(24177), Ar(24208), Esr1(24890), Esr2(25149), Shbg(24775). Pictograms: GHS08,GHS09. Signal Word: Danger. Hazard Statements: H351 - H360FD - H362 - H410. Precautionary Statements: P202 - P260 - P263 - P264 - P273 - P308 + P313. Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Lact. - Repr. 1A. Storage Class Code: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: Eyeshields, Gloves, type P2 (EN 143) respirator cartridges.