General description
DR6 is an orphan TNF receptor superfamily member belonging to a subgroup of receptors called death receptors. Expressed ubiquitously with high expression in lymphoid organs, heart, brain, and pancreas. Broadly expressed by developing neurons where it functions as pro-apoptotic factor. Recently, it has been reported that interaction with the beta-amyloid precursor protein (APP) activates a widespread caspase-dependent self-destruction program dependent on caspase-6.
Physical form
Lyophilized from PBS.
Reconstitution
Reconstitute with 50 μL deionized water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
Other Notes
The Fc portion of human IgG1 is fused to the C-terminus of human DR6 (aa 42-351).
- UPC:
- 12352112
- Condition:
- New
- HazmatClass:
- No
- MPN:
- SRP8028-50UG
- Temperature Control Device:
- Yes
akash.verma@cenmed.com
(732) 447-1115





