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jagged-2 (human): fc (human)

JAGGED-2 (HUMAN): FC (HUMAN)

Catalog No.
C005B-305756
Manufacturer No.
SRP8059-10UG
Manufacturer Name
Sigma-Aldrich
Quantity
1
Unit of Measure
EA

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General description Jagged-2 is a putative Notch ligand involved in the mediation of Notch signaling, that can induce stromal cells to secrete IL-6, VEGF and IGF-1. Notch activation can interact with NF-kappaB and C-myc to promote the

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General description

Jagged-2 is a putative Notch ligand involved in the mediation of Notch signaling, that can induce stromal cells to secrete IL-6, VEGF and IGF-1. Notch activation can interact with NF-kappaB and C-myc to promote the proliferation and to inhibit the apoptosis of MM cells, showing in the relationship between the incidence of myeloma and drug resistance. Jagged-2 is also involved in limb development.

Sequence

Human Jagged-2 (aa 1-1054) is fused at the C-terminus to the Fc portion of human IgG.

Physical form

Lyophilized. Contains PBS + 0.02 % CHAPS.

Reconstitution

Reconstitute with 100μl sterile water.

UPC:
12163001
Condition:
New
HazmatClass:
No
MPN:
SRP8059-10UG
Temperature Control Device:
Yes

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