DLK-IN-1 is a selective, orally active inhibitor of dual leucine zipper kinase (DLK, MAP3K12) , with a K i of 3 nM. DLK-IN-1 retains excellent CNS penetration and is well tolerated following multiple days of dosing at concentrations that exceed those required for DLK inhibition in the brain. DLK-IN-1 has activity in a model of Alzheimer’s Disease.Form:SolidIC50& Target:Ki: 3 nM (DLK).
Specifications and Purity: ≥99%
Molecular Formula: C20H24F3N5O2
Molecular Weight: 423.43
PubChem CID: 90292823
Isomeric SMILES: CC(C)N1C(=CC(=N1)C2=CC(=C(N=C2)N)OC(F)(F)F)C3[C@H]4[C@@H]3CN(C4)C5COC5
- UPC:
- 41104815
- Condition:
- New
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- D650308-50mg
- CAS:
- 1620574-24-4
- Product Size:
- 50mg
akash.verma@cenmed.com
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