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cytochrome p450 3a4 human

CYTOCHROME P450 3A4 HUMAN RECOMBINANT EXPRESSED IN E. COLI

Catalog No.
C005B-089172
Manufacturer No.
H5042-1000PMO
Manufacturer Name
Sigma-Aldrich
Quantity
1000
Unit of Measure
PM

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Supplied as purified soluble proteins, rather than microsomal preparations. Application Cytochrome P450 3A4 human has been used in circular dichroism analysis.

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General description

Supplied as purified soluble proteins, rather than microsomal preparations.

Application

Cytochrome P450 3A4 human has been used in circular dichroism analysis.

Biochem/physiol Actions

Cytochrome P450 3A4 (CYP3A4) is one of the isoform of cytochrome P450 (P450s). Cytochrome P450s (P450s) play a vital role in processing endogenous compounds and xenobiotics, including pollutants, environmental compounds and drug molecules. CYP3A4 oxidizes more than 90% of marketed drugs through various metabolic processes.

Unit Definition

One unit will convert 1.0 nanomole of testosterone to 6-beta-testosterone per minute at pH 7.4 at 37 °C.

Other Notes

Visit our drug metabolism resources: www.sigmaaldrich.com/life-science/metabolomics/enzyme-explorer/cell-signaling-enzymes/xenobiotics.html

biological source: human. Quality Level: 200. recombinant: expressed in E. coli. description: purified, soluble. form: liquid. specific activity: 12-200 . units/mg protein. mol wt: 57318.7 . g/mol. concentration: 3.5-25 . mg protein/mL (protein), 50-150 . nmol/mL (P450), 6-14 . nmol/mg protein (specific content). NCBI accession no.: NP_059488.2. shipped in: dry ice. storage temp.: −. 70°C. Gene Information: human ... CYP3A4(1576). Storage Class Code: 10 - Combustible liquids. WGK: WGK 2. Flash Point(F): Not applicable. Flash Point(C): Not applicable.
UPC:
51182008
Condition:
New
HazmatClass:
No
MPN:
H5042-1000PMO
CAS:
9035-51-2
Temperature Control Device:
Yes

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