CTOP

General description

A potent antagonist highly selective for µ opioid receptor (K_i = 0.96 nM for µ receptor and >10,000 nM for δ receptors). Often used for studying the functional roles of µ opioid receptors in both central and peripheral nervous systems.

Biochem/physiol Actions

Primary Target
mu opioid

Warning

Toxicity: Standard Handling (A)

Sequence

D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (Orn: ornithine; Pen: penicillamine; SS bond: 2-7)

Physical form

Supplied as trifluoracetate salt

Other Notes

Feng, Y., et al. 2012. Curr Drug Targets.13, 230.
Hawkins, N., et al. 1989. J. Pharmacol. Exp. Ther.248, 73.
Gulya, K., et al. 1988. Eur. J. Pharmacol.150, 355.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Molecular Weight: 1062.26. Empirical Formula: C₅₀H₆₇N₁₁O₁₁S₂. Assay: ≥. 98% (HPLC). Quality Level: 100. form: solid. potency: 0.96 . nM K_i. manufacturer/tradename: Calbiochem^®. . storage condition: OK to freeze, protect from light. color: white. solubility: water: soluble. storage temp.: −. 20°C. InChI: 1S/C50H67N11O11S2/c1-26(62)39(42(53)65)59-49(72)41-50(3,4)74-73-25-38(58-43(66)33(52)21-28-11-6-5-7-12-28)47(70)56-36(22-29-16-18-31(64)19-17-29)45(68)57-37(23-30-24-54-34-14-9-8-13-32(30)34)46(69)55-35(15-10-20-51)44(67)60-40(27(2)63)48(71)61-41/h5-9,11-14,16-19,24,26-27,33,35-41,54,62-64H,10,15,20-23,25,51-52H2,1-4H3,(H2,53,65)(H,55,69)(H,56,70)(H,57,68)(H,58,66)(H,59,72)(H,60,67)(H,61,71). InChI key: PZWWYAHWHHNCHO-UHFFFAOYSA-N. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable.