CTOP TFA is a potent and highly selective μ-opioid receptor antagonist. CTOP TFA antagonizes the acute analgesic effect and hypermotility. CTOP TFA enhances extracellular dopamine levels in the nucleus accumbens. CTOP TFA dose-dependently enhances locomotAppearance:SolidIC50& Target:μ Opioid Receptor/MORIn Vivo:CTOP TFA (0-0.5 nmol, ICV, once) antagonizes the analgesic effect in a dose-dependent manner. CTOP TFA (0-2 nmol, ICV, once) causes withdrawal hypothermia and a loss of body weight in animals. CTOP TFA (0-1.5 nmol per side, Intra-VTA injection)Biological Activity:CTOP TFA is a potent and highly selective μ-opioid receptor antagonist. CTOP TFA antagonizes the acute analgesic effect and hypermotility. CTOP TFA enhances extracellular dopamine levels in the nucleus accumbens. CTOP TFA dose-dependently enhances locomot.
Specifications and Purity: ≥99%
Molecular Formula: C52H68F3N11O13S2
Molecular Weight: 1176.28
- UPC:
- 12141741
- Condition:
- New
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- C659485-1mg
- Product Size:
- 1mg
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