Skip to main content
cp-alkyne

CP-ALKYNE

Catalog No.
C005B-254885
Manufacturer No.
930423-50MG
Manufacturer Name
Sigma-Aldrich
Quantity
50
Unit of Measure
MG

Log in for pricing

Application CP-alkyne is a probe that can be used to photochemically label tryptophans. A method was developed using cysteine-reactive compounds including this one to allow for unbiased analysis of proteomic data in quantitative applications

Enjoy exclusive benefits including discounted pricing on orders by contacting our Sales Executives to open an account. Contact Us

Application

CP-alkyne is a probe that can be used to photochemically label tryptophans. A method was developed using cysteine-reactive compounds including this one to allow for unbiased analysis of proteomic data in quantitative applications (Zanon et al. 2021). The method uses light or heavy labelling with the isotopically labelled desthiobiotin azide (isoDTB) tag for mass spectrometry analysis (Zanon et al. 2020). Analysis then uses the isotopic tandem orthogonal proteolysis activity-based protein profiling (isoTOP-ABPP) workflow (Weerapana et al. 2010, Backus et al. 2016)

Other Notes

1. Profiling the proteome-wide selectivity of diverse electrophiles

2. A quantitative thiol reactivity profiling platform to analyze redox and electrophile reactive cysteine proteomes

3. Ethynylation of Cysteine Residues: From Peptides to Proteins in Vitro and in Living Cells

4. A Chemoproteomic Platform To Assess Bioactivation Potential of Drugs

5. Inhibition of Zinc-Dependent Histone Deacetylases with a Chemically Triggered Electrophile

6. Reversibility of Covalent Electrophile-Protein Adducts and Chemical Toxicity

UPC:
12352003
Condition:
New
HazmatClass:
No
MPN:
930423-50MG

Cenmed Satisfaction Guarantee
Cenmed Satisfaction Guarantee

At Cenmed, your confidence and satisfaction are paramount. We guarantee the quality and reliability of our extensive range of clinical and laboratory supplies. If you're not completely satisfied with your purchase, we offer a straightforward return process and dedicated support to resolve your concerns promptly. Our commitment ensures that you can order with confidence, knowing that Cenmed is dedicated to superior service and customer satisfaction. Trust us to meet your needs with every order, backed by our promise of excellence. Learn more in Help & FAQs.

Testimonial
"Cenmed provides me access to the same products/services normally reserved for much larger labs than mine. I was presently surprised by their product offering."

LAB DIRECTOR

Testimonial
"We utilized Cenmed's capabilities for a variety of projects around the world. They are a valued partner and supplier."

PHARMACEUTICAL SUPPLY CHAIN LEADER

Testimonial
"The reps are very good at finding products for customers in this period of supply chain issues."

SCOTT BEHMAN

Testimonial
"Your customer service has been excellent and makes me excited about purchasing with Cenmed in the future!!"

PROCUREMENT + BILLING COORDINATOR AT PHARMA.

Lab - Point of Care

Lab Equipment & Accessories

Chemicals, Stains and Reagents

Medical Equipment

!