CODEINE--DEA SCHEDULE II ITEM

Application

Codeine monohydrate has been used as a standard in the quantitative analysis of codeine by using different types of protein assays like biuret, bicinchoninic acid (BCA), coomassie brilliant blue (CBB) , pyrogallol red–molybdate (PRM) assay, Lowry assay and benzethonium chloride (BEC) assay, while relating the effective response of the drug with the type of assay.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Weak narcotic analgesic, perhaps due to conversion to morphine, with minimal hypnotic properties; potent antitussive

Molecular Weight: 317.38. Empirical Formula: C₁₈H₂₁NO₃ · H₂O. grade: analytical standard. Quality Level: 200. Agency: EPA 1694. drug control: USDEA Schedule II. Home Office Schedule 2. stupéfiant (France). kontrollierte Droge in Deutschland. regulated under CDSA - not available from Sigma-Aldrich Canada. estupefaciente (Spain). Decreto Lei 15/93: Tabela IA (Portugal). technique(s): HPLC: suitable, gas chromatography (GC): suitable. application(s): clinical testing. format: neat. storage temp.: 2-8°C. SMILES string: CN1[C@H](C2)[C@@]3([H])[C@@]4(CC1)C5: C2C: CC(OC): C5O[C@@]4([H])[C@@H](O)C: C3.O. InChI: 1S/C18H21NO3.H2O/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19. /h3-6,11-13,17,20H,7-9H2,1-2H3. 1H2/t11-,12+,13-,17-,18-. /m0./s1. InChI key: WRRSFOZOETZUPG-FFHNEAJVSA-N. Gene Information: human ... CYP2D6(1565), OPRD1(4985), OPRK1(4986), OPRM1(4988)
rat ... Cyp2d1(266684), Cyp2d2(25053), Cyp2d3(24303), Cyp2d4v1(171522). Pictograms: GHS07. Signal Word: Warning. Hazard Statements: H302. Precautionary Statements: P264 - P270 - P301 + P312 - P501. Hazard Classifications: Acute Tox. 4 Oral. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Faceshields, Gloves.