COCAINE HYDROCHLORIDE--DEA SCHEDULE II ITEM (C005B-046960)

Application

Cocaine hydrochloride has been used:

• in saline control to study the effects of cocaine self-administration in mouse brain
• as adopamine (DA), noradrenaline (NA), and serotonin (5-HT) reuptake inhibitor to evoke neurotransmitter release in artificial fish cerebrospinal fluid (aCSF)
• to examine conditioning to intravenous cocaine hydrochloride

Biochem/physiol Actions

Inhibits the dopamine, norepinephrine, and serotonin transporters with K_is of about 300 nM, 900 nM, and 400 nM, respectively. Unlike amphetamines, it has no effect on catecholamine release.

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Molecular Weight: 339.81. Empirical Formula: C₁₇H₂₁NO₄ · HCl. form: powder. Quality Level: 200. drug control: USDEA Schedule II. Home Office Schedule 2. stupéfiant (France). kontrollierte Droge in Deutschland. regulated under CDSA - not available from Sigma-Aldrich Canada. estupefaciente (Spain). Decreto Lei 15/93: Tabela IB (Portugal). application(s): forensics and toxicology. SMILES string: Cl.COC(: O)[C@H]1[C@H](C[C@@H]2CC[C@H]1N2C)OC(: O)c3ccccc3. InChI: 1S/C17H21NO4.ClH/c1-18-12-8-9-13(18)15(17(20)21-2)14(10-12)22-16(19)11-6-4-3-5-7-11. /h3-7,12-15H,8-10H2,1-2H3. 1H/t12-,13+,14-,15+. /m0./s1. InChI key: PIQVDUKEQYOJNR-VZXSFKIWSA-N. Pictograms: GHS06,GHS08. Signal Word: Danger. Hazard Statements: H300 + H330 - H336 - H361d. Precautionary Statements: P202 - P260 - P264 - P271 - P280 - P304 + P340 + P310. Hazard Classifications: Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Repr. 2 - STOT SE 3. Target Organs: Central nervous system. Storage Class Code: 6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges.