Cdk4 inhibitor

Cdk4 Inhibitor is a cell-permeable, unsymmetrical indolocarbazole compound that displays antiproliferative properties. Acts as a potent, selective, and ATP-competitive inhibitor of Cdk4/cyclin D1 (IC|50|= 76 nM). It inhibits the activity of other Cdk's only at much higher concentrations (IC|50|= 520 nM and 2.1 μM for Cdk2/cyclin E and Cdc2 (Cdk1)/cyclin B, respectively) and shows little activity towards CaMKII, PKA, or GSK-3b (IC|50|≥ 12.4 μM). Shown to inhibit tumor cells growth (IC|50|< 3.0 μM in HCT-116 and NCI-H460 cells) by blocking Rb phosphorylation and inducing G1 cell cycle arrest.

Molecular Formula: C20H10BrN3O2

Molecular Weight: 404.22

PubChem CID: 5330797

Isomeric SMILES: C1=CC=C2C(=C1)C3=C4C(=C5C6=C(C=C(C=C6)Br)NC5=C3N2)C(=O)NC4=O

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