Cdk4/6 Inhibitor IV

Cdk4/6 Inhibitor IV is a cell-permeable triaminopyrimidine compound acting as a reversible and ATP-competitive inhibitor of Cdk4/6 (IC|50|= 1.5 μM and 5.6 μM for Cdk4/D1 and Cdk6/D1, respectively) with selectivity over Cdk5/p35 (IC50 = 25 μM), v-abl, c-met, IGF-1R and IR (IC|50|> 10 μM), Cdk2/A, Cdk2/E, Cdk4/D2, Cdk6/D2 (IC50 > 50 μM) and Cdk1/B (IC|50|> 100 μM). Cdk4/6 Inhibitor IV exhibits blocking of pRb phosphorylation at Ser780 and Ser795, induce cell cycle arrest (G0/G1), and apoptosis in U2OS and MRC-5 cells at 5 - 10 μM. Further, suppresses tumor growth in Xenograft mouse model (30 mg/kg, i.p.).

Specifications and Purity: ≥95%

Molecular Formula: C27H32N6O

Molecular Weight: 456.58

PubChem CID: 24825971

Isomeric SMILES: CCNC1=CC(=NC(=N1)NC2=CC3=C(C=C2)N(C=C3)CC4=CC=CC=C4)NC5CCC(CC5)O

Related Documents: https://aladdin-for-icloud-store.oss-cn-hangzhou.aliyuncs.com/aladdinsci/pdp/sds/1/C336771-SCI_d1bf466966667e09e8d8a72fb4250f82.pdf