CATHEPSIN L INHIBITOR IV 1PC X 1MG

General description

A potent, cell-permeable, selective, and reversible inhibitor of cathepsin L (IC₅₀ = 1.9 nM). Also inhibits the release of Ca²⁺ and hydroxyproline from bone in an in vitro bone culture system and prevents bone loss in ovariectomized mice (~50 mg/kg).

A potent, cell-permeable, selective, and reversible inhibitor of cathepsin L (IC₅₀ = 1.9 nM). Inhibits the release of Ca²⁺ and hydroxyproline from bone in a bone culture system and prevents bone loss in ovariectomized mice (~50 mg/kg).

Biochem/physiol Actions

Cell permeable: yes

Primary Target
cathepsin L

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 1.9 nM against Cathepsin L

Warning

Toxicity: Standard Handling (A)

Sequence

1-Naphthalenesulfonyl-Ile-Trp-CHO

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Yasuma, T., et al. 1998. J. Med. Chem. 41, 4301.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Molecular Weight: 491.60. Empirical Formula: C₂₇H₂₉N₃O₄S. Quality Level: 100. Assay: ≥. 98% (HPLC). form: solid. manufacturer/tradename: Calbiochem^®. . storage condition: OK to freeze. color: white to off-white. solubility: DMSO: 5 . mg/mL. shipped in: ambient. storage temp.: −. 20°C. Storage Class Code: 11 - Combustible Solids. WGK: WGK 1. Flash Point(F): Not applicable. Flash Point(C): Not applicable.