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cathepsin l inhibitor, caa0225 - calbiochem

CATHEPSIN L INHIBITOR CAA02 1PC X 1MG

Catalog No.
C005B-098136
Manufacturer No.
219502-1MG
Manufacturer Name
Calbiochem
Quantity
1
Unit of Measure
MG

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An epoxysuccinyl peptide highly selective for rat liver cathepsin L (IC 50 = 1.9 nM), while exhibiting little to no effect on rat liver cathepsin B at concentrations higher than 1000-5000 nM, in vitro .

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General description

An epoxysuccinyl peptide highly selective for rat liver cathepsin L (IC50 = 1.9 nM), while exhibiting little to no effect on rat liver cathepsin B at concentrations higher than 1000-5000 nM, in vitro. During autophagy, it has been shown through immunoblotting that CAA0225 (10 µg/ml) effectively inhibits the degradation of LC3-II and GABARAP compared to control, in nutrient-deprived HeLa and Huh-7 cells.

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Takahashi, K., et al. 2009. Biol. Pharm. Bull.32, 475.
Ueno, T., et al. 2009. Autophagy5, 878.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Molecular Weight: 487.55. Empirical Formula: C28H29N3O5. Assay: ≥. 95% (HPLC). Quality Level: 100. form: solid. manufacturer/tradename: Calbiochem®. . storage condition: OK to freeze. color: white. solubility: DMSO: 100 . mg/mL. shipped in: wet ice. storage temp.: −. 20°C.
UPC:
51171501
Condition:
New
HazmatClass:
Yes
MPN:
219502-1MG
Temperature Control Device:
Yes

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