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boc-asp(ome)-fluoromethyl ketone

N-T-BOC-ASP(OME)-FLUOROMETHYL KETONE

Catalog No.
C005B-023138
Manufacturer No.
B2682-3MG
Manufacturer Name
Sigma-Aldrich
Quantity
3
Unit of Measure
MG

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Application Boc-Asp(OMe)-fluoromethyl ketone (Boc-D-fmk) has been used as a caspase inhibitor to study its effects on lactate dehydrogenase (LDH) leakage, apoptosis and virus proliferation in chorion cells , as a component of the transplantation

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Application

Boc-Asp(OMe)-fluoromethyl ketone (Boc-D-fmk) has been used as a caspase inhibitor to study its effects on lactate dehydrogenase (LDH) leakage, apoptosis and virus proliferation in chorion cells , as a component of the transplantation medium for the transplantation of human embryonic stem cells (ESC)-derived medial ganglionic eminence (MGE) cells into hippocampus of mice , as a protease inhibitor to study its effects on cell death in parasites .

Biochem/physiol Actions

Boc-Asp(OMe)-fluoromethyl ketone (Boc-D-fmk) permits cell permeability. It is a caspase inhibitor and suppresses apoptosis induced by various kinds of stimuli. Boc-D-fmk poorly inhibits caspases-2, -5, -6 and -10.

Molecular Weight: 263.26. Empirical Formula: C11H18NO5F. Quality Level: 100. Assay: ≥. 90% (TLC). form: solid. solubility: DMF: soluble. storage temp.: −. 20°C. SMILES string: COC(: O)C[C@H](NC(: O)OC(C)(C)C)C(: O)CF. InChI: 1S/C11H18FNO5/c1-11(2,3)18-10(16)13-7(8(14)6-12)5-9(15)17-4/h7H,5-6H2,1-4H3,(H,13,16)/t7-/m0/s1. InChI key: MXOOUCRHWJYCAL-ZETCQYMHSA-N. Pictograms: GHS07. Signal Word: Warning. Hazard Statements: H319. Precautionary Statements: P264 - P280 - P305 + P351 + P338 - P337 + P313. Hazard Classifications: Eye Irrit. 2. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: Eyeshields, Gloves, type N95 (US).
UPC:
12141905
Condition:
New
HazmatClass:
No
MPN:
B2682-3MG
CAS:
187389-53-3

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