BOC-ASN(TRT)-OH 25 G

General description

A trityl-protected derivative which increases the solubility of Asn during the coupling step in SPPS ^[1]. Its use gives higher yields and lower by-product formation. During the following coupling cycles the temporary side-chain protection is removed.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Boc SPPS

Literature references

^[1] P. Sieber, et al. (1991) Tetrahedron Lett., 32, 739.

Linkage

Replaces: 04-12-0187

Analysis Note

Colour (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Optical rotation α 25/D (c=1 in methanol): -21.5 - -16.5 °
Purity (TLC(011A)): ≥ 98 %
Purity (TLC(0811)): ≥ 98 %
Solubility (1 mmole in 2 ml DMF): clear solution

To see the solvent systems used for TLC of Novabiochem^® products please click here.

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Molecular Weight: 474.55. Empirical Formula: C₂₈H₃₀N₂O₅. Quality Level: 200. product line: Novabiochem^®. . Assay: ≥. 98% (TLC). form: powder. reaction suitability: reaction type: Boc solid-phase peptide synthesis. manufacturer/tradename: Novabiochem^®. . application(s): peptide synthesis. functional group: amide. storage temp.: 15-25°C. InChI: 1S/C28H30N2O5/c1-27(2,3)35-26(34)29-23(25(32)33)19-24(31)30-28(20-13-7-4-8-14-20,21-15-9-5-10-16-21)22-17-11-6-12-18-22/h4-18,23H,19H2,1-3H3,(H,29,34)(H,30,31)(H,32,33)/t23-/m0/s1. InChI key: PYGOCFDOBSXROC-QHCPKHFHSA-N. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable.